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Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial

Objective: To assess the effect of treatment with a combination of clomiphene citrate as an antiestrogen and vitamin E as an antioxidant on the incidence of pregnancy and sperm variables in men with idiopathic oligozoospermia and infertility.Design: Prospective, randomized, placebo-controlled trial.Setting: The outpatient andrology clinic at a university hospital.Patient(s): Sixty infertile men with idiopathic oligoasthenozoospermia.Intervention(s): […]

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The views of adult offspring of sperm donation: essential feedback for the development of ethical guidelines within the practice of assisted reproductive technology in the United States

Objective: To provide an in-depth analysis of offspring attitudes toward their means of conception and the practice of sperm donation in the United States.Design: Survey-based study using a 46-item questionnaire.Patient(s): Eighty-five adult offspring of sperm donation.Intervention(s): Participants were recruited through an Internet-based support group for adults conceived through sperm donation. Eighty-five of them completed the […]

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Double probing individual human spermatozoa: aniline blue staining for persistent histones and fluorescence in situ hybridization for aneuploidies

Objective: To study the potential relationship between two sperm nuclear attributes: persistence of histones and occurrence of chromosomal aneuploidies.Design: The two variables were examined by double probing of the same spermatozoa.Setting: Academic Andrology Laboratory.Patient(s): Semen samples subjected for analyses were examined.Intervention(s): We studied >58,000 spermatozoa, in seven men, first with aniline blue histone staining, graded […]

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Follicular fluid levels of anti-Mullerian hormone as a predictor of oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome

Objective: To test whether the follicular fluid (FF) concentration of anti-Mullerian hormone (AMH) is associated with oocyte maturation, fertilization rate, and embryonic development in patients with polycystic ovary syndrome (PCOS) undergoing IVF.Design: Prospective.Setting: Academic assisted reproductive technology program.Patient(s): Twenty-two samples of FF from 11 patients with PCOS who underwent IVF/ET were analyzed for AMH levels […]

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Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination

Objective: To measure activin A concentrations in uterine washing fluid collected from women with couple infertility undergoing intrauterine insemination (IUI).Design: Retrospective case-control study.Setting: Tertiary university center for women's care.Patient(s): Fifty women, of whom 25 became pregnant after up to three IUI attempts and 25 did not.Intervention(s): Endocrine and clinical evaluation, semen analyses and hypo-osmotic swelling […]

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The psychosocial transition associated with spontaneous 46,XX primary ovarian insufficiency: illness uncertainty, stigma, goal flexibility, and purpose in life as factors in emotional health

Objective: To examine factors associated with emotional well-being in women with spontaneous primary ovarian insufficiency.Design: Cross-sectional and case–control study.Setting: Clinical research center, national U.S. health research facility.Patient(s): Women diagnosed with spontaneous 46,XX primary ovarian insufficiency (n = 100) at a mean age of 32.4 years and healthy control women of similar age (n = 60).Intervention(s): […]

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Anti-?2-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy loss

Objective: To evaluate the role of anti-?2-glycoprotein-I (anti-?2GPI-ab) and anti-phosphatidylserine (aPS-ab) antibodies as a risk factor in both recurrent miscarriage (RM) and unexplained fetal losses (UFL).Design: Retrospective, cohort study.Setting: Vall d'Hebron University Hospital, Barcelona, Spain.Patient(s): 122 pregnant women divided in two groups: study group of 54 women with RM and/or UFL and control group of […]

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N- and E-cadherin expression in human ovarian and urogenital duct development

Objective: To investigate expression of N- and E-cadherin in the developing human ovary.Design: The expression of N- and E-cadherin was analyzed in 18 human fetal ovaries between 8 and 20 weeks' gestation using immunohistochemistry. Fetal human male and rat urogenital tracts were used for comparison of expression.Setting: Academic research institute.Patient(s): Women undergoing termination of pregnancy.Intervention(s): […]

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Age-related variations in follicular apolipoproteins may influence human oocyte maturation and fertility potential

Objective: To investigate involvement of specific apolipoproteins in the process of human oocyte maturation and age-related infertility as molecular constituents of follicular fluid.Design: Laboratory-based observational study.Setting: Basic science laboratory at a large academic institution.Patient(s): Follicular fluid obtained from healthy women aged 18 to 45 years undergoing in vitro fertilization for unexplained infertility, ovulatory dysfunction, tubal […]

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Enhanced expressions of matrix metalloproteinase (MMP)-2 and –9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding

Objective: To evaluate the roles of endometrial matrix metalloproteinase (MMP)-2 and -9, vascular endothelial growth factors (VEGF), and microvascular density (MVD) in the occurrence of anovulatory dysfunctional uterine bleeding (DUB).Design: A prospective analytical design.Setting: The obstetrics and gynecology department of an academic training hospital.Patient(s): Sixty women with anovulatory DUB and 20 control women.Intervention(s): Endometrial biopsies […]

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Aberration of blastocyst microRNA expression is associated with human infertility

Objective: To examine human blastocyst microRNA (miRNA) expression in correlation with human infertility. MicroRNAs are small, noncoding RNA molecules that regulate gene expression via mechanisms such as degradation and translational suppression of targeted messenger RNAs. Recent data has pointed to the importance of miRNAs in disease states and during mouse embryo development.Design: Descriptive study.Setting: Nonprofit […]

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Reconstruction of endometrium in vitro via rabbit uterine endometrial cells expanded by sex steroid

Objective: To culture rabbit endometrial cells by using sex steroids to provide adequate seeding cells for endometrium reconstruction and uterine tissue engineering.Design: Prospective experimental study.Setting: Beijing Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences.Animal(s): New Zealand rabbit and Kunming white strain mice.Intervention(s): Rabbits were primed with pregnant mare […]

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Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: A randomized, double blind, placebo-controlled trial

Objective: To evaluate the effectiveness of sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women.Design: Placebo-controlled, double-blind, randomized trial.Setting: University hospital.Patient(s): Fifty-two women with an indication for diagnostic hysteroscopy.Intervention(s): Randomized women who had received either 200 ?g of misoprostol (n = 25) or placebo (n = 27) sublingually 2 hours before hysteroscopy. Two […]

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Preimplantation genetic diagnosis (PGD) for extremes—successful birth after PGD for a consanguineous couple carrying an identical balanced reciprocal translocation

Objective: To report a healthy birth after preimplantation genetic diagnosis (PGD) performed for a consanguineous couple carrying an identical familial reciprocal translocation in both partners.Design: Case report.Setting: In vitro fertilization (IVF) clinic and genetic laboratory in a private hospital.Patient(s): Consanguineous couple carrying the same balanced reciprocal translocation: 46,XX,t(1;16)(q12;q11.2) and 46,XY,t(1;16)(q12;q11.2).Intervention(s): 25 oocyte–cumulus complexes were retrieved […]

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Rockin my bands

So FEDEX calls and says my package will be delivered within two hours. Cool. The customs due is 87LE, approx. 16.00. OK.... for what i ask her? She says customs are decided by the government and not FEDEX and she will include the invoice and a number for customsI can call. See here's the thing. […]

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Back to our regularly scheduled programing

We are all well knocking on wood. It was a rough 2 weeks there. Everyone is feeling much better. Gary finally had to go get an allergy shot to feel better. Abby, by far, was the worst hit and took the longest to be herself. I have never seen her so sick.She did a lot […]

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Pregnancy Termination With Drugs Or Pills

Whenever the decision for pregnancy termination is taken by a woman, it is not one taken lightly.Pregnancy termination can be done by use of drugs when it is known as medication abortion or medication pregnancy termination.This does not involve any surgical procedure; rather it is the administration of an abortifacient. This abortifacient could be administered […]

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Getting Fit After Having A Baby

During pregnancy, a woman’s body will undergo many changes. One unpopular change during pregnancy is an increase in weight which can often be up to 50 pounds.Unfortunately, after giving birth, you not only take your newborn back home, but also the extra weight. One of the first things you want to do after giving birth […]

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Breast milk kills cancers claim scientists

In new evidence set to spark debate over whether breastfeeding is best, scientists have found breast milk provides a natural immunity boost for youngsters.The same compound, Human Alpha-lactalbumin Made Lethal to Tumour cells or HAMLET, could be a common cancer treatment for adults within five years. Human trials have shown HAMLET can kill bladder cancer […]

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Against Their Will: Special Series on the History of Forced Sterilization in North Carolina

Via FWD/Forward, I learned about this series from the Winston-Salem Journal on forced sterilization in North Carolina. A snippet:The Winston-Salem Journal obtained and examined thousands of these documents. It found that:More than 2,000 people ages 18 and younger were sterilized in many questionable cases, including a 10-year-old who was castrated. Children were sterilized over the […]

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Obesity Or Smoking During Pregnancy Can Lower Sperm Count In Sons

We all know that smoking during pregnancy is a complete no-no for a variety of reasons and there is increasing evidence to show that obesity is bad as well for the mother and child. And now it would seem that these two pernicious factors have the power to influence future generations as well.Lower sperm counts […]

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Vera Farmiga Expecting Second Child!

Vera Farmiga and her hubby, Renn Hawkey, are expecting their second child, In Touch reports.The Up in the Air star was set to play the wife of actor Gerard Butler in the upcoming film Machine Gun Preacher, but had to drop out after discovering she was pregnant again. "She is three months pregnant and due […]

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Six months pregnant woman finishes Boston Marathon in 4:21

For more than four hours Monday, Urbandale's Leah Newman bounded along the streets of Boston as she mulled over possible names for her next son.The pondering proved more than hypothetical. After all, her son was along for the ride.Newman, 35, finished the Boston Marathon while six months pregnant."I spent 26 miles trying to find the […]

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In Effort to Limit C-Sections, a Look at Two Hospitals

This is a tale of two hospitals.One has the highest rate of Cesarean sections in the city, the other the fourth lowest. They represent some of the city's obstetric extremes, yet they sit just five miles apart on Staten Island, serving similar populations.So what accounts for the difference?In large part, determination, which Dr. Mitchell A. […]

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In Vitro Maturation (IVM) of immature human eggs: Will Fertility Drugs Become Unnecessary for IVF?

In the mid?1990s a group at Monash University in Melbourne, Australia, reported the world's first baby born from an embryo derived from an immature egg that had been matured in the embryology laboratory, and then fertilized and transferred to the uterus. The process has come to be known as In vitro maturation (IVM) of eggs. […]

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