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Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation

Objective: To map the changes in messenger RNA (mRNA) and protein abundance during the window of implantation in specifically endometrial stromal and glandular epithelial cells obtained using laser microdissection microscopy (LDM).Design: Endometrial samples were collected from two menstrual cycles at 2 and 7 days after first significant rise in blood LH, and separate cell populations […]

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Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization

Objective: To assess the impact of elevated peak serum E2 levels (EPE2; defined as levels >90th percentile) on the day of hCG administration during controlled ovarian hyperstimulation (COH) for IVF on the likelihood for small for gestational age (SGA), preeclampsia (PreE), and preterm delivery (PTD) in singleton pregnancies.Design: Retrospective cohort study.Setting: Tertiary-care academic medical center.Patient(s): […]

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Peritoneal cytokines and adhesion formation in endometriosis: an inverse association with vascular endothelial growth factor concentration

Objective: To evaluate inflammatory/angiogenic cytokines—interleukin-1? (IL-1?), IL-6, IL-8, IL-12, interferon-? (IFN-?), tumor necrosis factor (TNF), and vascular endothelial growth factor A (VEGF-A)—in the peritoneal fluid of patients with endometriosis in relation to the occurrence and severity of pelvic adhesions and in control women without pelvic pathology.Design: Case-control study.Setting: University research institution and hospital.Patient(s): Sixty-five women […]

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Association between the location of transposed ovary and ovarian function in patients with uterine cervical cancer treated with (postoperative or primary) pelvic radiotherapy

Objective: To evaluate the effectiveness of ovarian transposition procedures in preserving ovarian function in relation to the location of the transposed ovaries in patients who underwent surgery with or without pelvic radiotherapy.Design: Retrospective.Setting: Uterine cancer center.Patient(s): A total of 53 patients with cervical cancer who underwent ovarian transposition between November 2002 and November 2010.Intervention(s): Ovarian transposition […]

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Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue

Objective: To investigate ovarian reserve and ovarian function in women transplanted with frozen/thawed ovarian tissue.Design: Retrospective cohort study.Setting: University hospital.Patient(s): 18 women transplanted with their own frozen/thawed ovarian tissue.Intervention(s): None.Main Outcome Measure(s): Levels of antimüllerian hormone (AMH), duration of function of the transplanted ovarian tissue, outcome of assisted reproduction.Result(s): Of the 18 women who received […]

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Effect of escitalopram on hot flash interference: a randomized, controlled trial

Objective: To estimate the effect of escitalopram (10–20 mg/d) versus placebo for reducing hot flash interference in daily life and understand correlates and predictors of reductions in hot flash interference, a key measure of quality of life.Design: Multisite, randomized, double-blind, placebo-controlled clinical trial.Setting: MsFLASH clinical sites in Boston, Indianapolis, Oakland, and Philadelphia.Patient(s): A total of […]

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Influence of embryo transfer on embryo preimplantation development

Objective: To investigate the impact of injection speeds of the transferred load on embryo development.Design: A laboratory model for in vitro simulation of ET was developed to investigate the impact of varying injection speeds of the transferred load on embryo development.Setting: Academic research institutes of reproduction biotechnology and private centers of reproductive medicine.Animal(s): Mouse hybrid F1 […]

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Suppression of spermatogenesis before grafting increases survival and supports resurgence of spermatogenesis in adult mouse testis

Objective: To test whether absence of complete spermatogenesis in mature testicular tissue before grafting will increase graft survival.Design: Prospective experimental study.Setting: Laboratory.Animal(s): Donor testes were obtained from adult untreated mice, adult mice rendered cryptorchid, and adult mice treated with a GnRH antagonist (acyline).Intervention(s): Donor testes were ectopically grafted to nude mice and recovered at three […]

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Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis

Objective: To determine the effects of all-trans-retinoic acid (RA) on establishment and growth of endometrial lesions, peritoneal interleukin-6 (IL-6) and macrophage chemotactic factor-1 (MCP-1) concentrations, and CD38, CD11b, and F4/80 expression on peritoneal macrophages in an immunocompetent mouse model of endometriosis.Design: Experimental transplantation study using mice.Setting: Academic medical center.Animal(s): C57BL/6 recipient mice and syngeneic green […]

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Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes

Objective: To determine whether the high lipid content of human follicular fluid influences oocyte maturation.Design: Mouse oocytes as substitutes for human oocytes were exposed to follicular fluids of differing lipid content with outcome monitoring.Setting: Private infertility clinic and university laboratory.Patient(s): Seventy-four women seeking assisted reproduction, and gonadotropin-stimulated mice.Intervention(s): Assay of follicular fluids for triglyceride and […]

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Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period

Objective: To evaluate morphometric-stereological changes in the epididymal caput, sperm quality, and fertility parameters in rats treated with finasteride and after a 30-day post-treatment recovery period.Design: Experimental study in a research laboratory.Setting: Reproductive biology research laboratory.Animal(s): Male and female Sprague Dawley rats.Intervention(s): Treatment with finasteride (5 mg/kg/day) for 56 days followed by 30 days without […]

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Smad7 is a transforming growth factor-beta–inducible mediator of apoptosis in granulosa cells

Objective: To determine the functional role of Smad7 in granulosa cells.Design: Granulosa cell culture and molecular biological techniques were used to investigate regulation and function of Smad7.Setting: Research laboratory.Animal(s): C57bl/j hybrid mouse.Intervention(s): Primary mouse granulosa cells were isolated and grown in culture for all messenger RNA expression experiments. Smad7 promoter constructs were evaluated with a […]

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Aromatase expression in abdominal omental/visceral and subcutaneous fat depots: a comparison of pregnant and obese women

Objective: To investigate total and promoter expression of aromatase in subcutaneous and omental (visceral) fat and compare this expression in pregnant and obese women.Design: Cross-sectional study.Setting: Academic hospital.Patient(s): Six women undergoing elective cesarean section and three women undergoing bariatric surgery.Intervention(s): Subcutaneous and omental fat obtained during surgery.Main Outcome Measure(s): Total aromatase and promoter expression was […]

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The risk of gestational diabetes mellitus among Mexican women with a history of infertility and polycystic ovary syndrome

Objective: To study the incidence of gestational diabetes mellitus (GDM) in Mexican women with a history of infertility and polycystic ovary syndrome (PCOS) compared with women without PCOS matched by age, pregestational body mass index (BMI), and parity.Design: Historic cohort study.Setting: Level three medical institution.Patient(s): Group 1 (n = 52), women with a history of […]

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Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimüllerian hormone levels

Objective: To investigate the effect of laparoscopic endometrioma stripping on serum antimüllerian hormone (AMH) and the correlation between the clinicopathologic factors.Design: Prospective study.Setting: University hospital.Patient(s): Sixty-five women with endometriomas.Intervention(s): All patients underwent laparoscopic cystectomy. Serum AMH, FSH, LH, E2, and antral follicle count (AFC) were measured preoperatively, at 6 weeks, and at 6 months postoperatively. […]

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Congress may create trouble in MP during Bharat bandh: BJP – Daily News & Analysis

Zee NewsCongress may create trouble in MP during Bharat bandh: BJPDaily News & AnalysisPlace: Bhopal | Agency: PTI The ruling BJP in Madhya Pradesh on Wednesday claimed that Congress workers under the garb of saffron activists may create "disturbance" during the day-long nationwide bandh tomorrow on the issue of steep hike in petrol ...Petrol price […]

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Stir against petro price hike today – Deccan Herald

The HinduStir against petro price hike todayDeccan HeraldNormal life across the country is likely to be hit on Thursday as Opposition parties and some partners of the ruling UPA have called for nationwide bundh in protest against the steep hike in petrol prices. The Bharat bundh will have support of the ...Karuna rolls back pull-out […]

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Anand wins fifth World Chess Championship after beating Gelfand – Hindustan Times

Hindustan TimesAnand wins fifth World Chess Championship after beating GelfandHindustan TimesAs champion Viswanathan Anand and his Israeli challenger Boris Gelfand kept playing out one draw after another with the classical games producing just one win for either player, there were concerns whether India's four-time world champion was finally ...Anand sprints,marathon endsIndian ExpressViswanathan Anand says he […]

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Fight escalates, government tells Team Anna no probe – Hindustan Times

The HinduFight escalates, government tells Team Anna no probeHindustan TimesA day after Prime Minister Manmohan Singh threatened to quit public life if Team Anna could prove its corruption allegations against him, the face-off between the two sides escalated. The government on Wednesday rejected Team Anna's demand for a ...Team Anna tones down rhetoric against govtDeccan […]

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Pneumonia – symptoms, causes, and preventive measures

Pneumonia is a lung infection that can make you very sick. You may cough, run a fever, and have a hard time breathing. For most people, pneumonia can be treated at home. It often clears up in 2 to 3 weeks. But older adults, babies, and people with other diseases can become very ill. They […]

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Turkey: Erdogan’s Anti-Abortion Comments Spark Criticism

Womens rights activists and feminists have condemned comments by the Prime Minister of Turkey calling for a reduction in the number of abortions in the country. We are preparing a law on abortion and we will enact this law, Recep Tayyip Erdogan told hundreds of people at a new hospital in Istanbul

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New Urinary Catheter May Reduce Complications Associated With Current Devices

Editor's Choice Main Category: Urology / Nephrology Article Date: 29 May 2012 - 9:00 PDT Current ratings for: 'New Urinary Catheter May Reduce Complications Associated With Current Devices' 5 (1 votes) "Significant complications may result from urethral trauma due to inappropriate catheter inflation within the urethra including severe pain, bleeding, and infection, all of which prolong hospitalization and increase cost," said David Aaronson, MD, a urologist with Safe Medical Devices, LLC, in San Francisco.

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EDAP Showcases Innovative Devices at American Urology Annual Meeting

Ablatherm-HIFU receives best poster award Unprecedented interest and attendance at EDAP's booth from U.S.

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The Alarming Health Risks Associated With Teen Pregnancy

Kristina's story on tonight's episode of"16 and Pregnant" was incredibly moving. Not only did she lose her fianc right after she found out she was pregnant, but she was also admitted to the hospital for the last two months of her pregnancy because of health complications. Her doctors realized the baby was not developing like he should be and that her fluid levels were dangerously low

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Surprise pregnancy for Emmerdale's Gennie

Emmerdale star Sian Reese-Williams has revealed Gennie Walker's surprise pregnancy could unite her with boyfriend Nikhil Sharma. Gennie is terrified when she discovers she is pregnant and puts off telling her boyfriend, played by Rik Makarem, as she thinks he doesn't want children. But Sian revealed to PA: "I think he's going to surprise her with his reaction to the news.

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