Archive for Fertility News



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Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes

Objective: To investigate the effect of vitrification on Dnmt1o, Hat1, and Hdac1 promoter CpG island methylation patterns and messenger RNA (mRNA) expression levels in mouse metaphase II (MII) oocytes.Design: In vitro study.Setting: Academic institution.Animal(s): Kunming white mice.Intervention(s): After vitrification, surviving mouse MII oocytes subjected to methylation and expression analysis with fresh oocytes used as a control.Main […]

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Aging sperm negatively impacts in vivo and in vitro reproduction: a longitudinal murine study

Objective: To investigate the impact of paternal aging on reproductive success.Design: Animal study.Setting: Research facility.Animal(s): Outbred CF1 mice.Intervention(s): Ten young male mice with proven fertility were mated routinely over 15 months with superovulated young females to assess in vivo and in vitro reproductive outcome.Main Outcome Measure(s): In vivo fertilization, in vivo fetal development, in vitro embryo morphology, and developmental outcome […]

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Identification of a novel sperm motility–stimulating protein from caprine serum: its characterization and functional significance

Objective: To identify and characterize a novel sperm motility–stimulating protein (MSP) from caprine serum.Design: Prospective experimental study.Setting: Research laboratory.Animal(s): Rabbits and male and female BALB/c mice.Intervention(s): Protein purification by conventional methods and functional and immunological characterization.Main Outcome Measure(s): MSP was purified, purity was checked, and molecular weight was determined. Surface localization, tissue distribution, and IVF […]

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Current status of uterus transplantation in primates and issues for clinical application

Objective: To clarify the current status of uterus transplantation (UT) and the medical, ethical, and social problems surrounding UT.Design: Systematic review.Setting: Not applicable.Patient(s): Mainly nonhuman primates and humans.Intervention(s): Not applicable.Main Outcome Measure(s): A systematic search of Pubmed with the terms “uterus/uterine transplantation” was performed for English-language articles to review the current status of UT and […]

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Infertility During Pregnancy

How relevant is infertility during pregnancy? I used to think that there was a definitive cure to infertility having a child. But now that Im in my second trimester awaiting the arrival of our first baby thanks to the gift of embryo adoption, I see that infertility at least our infertility wont just go away. […]

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Retreat for Those Experiencing Infertility

Five couples and four women without their husbands in tow usher into the conference room. We drove various distances to be here. Some from Virginia, some from North Carolina and Pennsylvania, and some from the other end of West Virginia, where our retreat house is located. Weve been married anywhere from less than 2 years […]

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Wayne State University Physician Group

About this practiceSince 1868, the Wayne State University School of Medicine has been educating physicians and engaging in biomedical research. The Wayne State University Physician Group consists of physicians who are faculty and researchers at the School of Medicine who build the latest developments in medical education and research into their clinical practice.?Wayne State University […]

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Scientific overview of hormone treatment used for rejuvenation

A search for a hormonal fountain of youth has been hotly pursued over the last century, predominately by those who wish to market hormones to a gullible public. There is little or no benefit of hormone replacement in persons who do not have a hormone deficiency. Overall, the present state of the art suggests that […]

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Effect of rejuvenation hormones on spermatogenesis

Objective: To review the current literature for the effect of hormones used in rejuvenation clinics on the maintenance of spermatogenesis.Design: Review of published literature.Setting: Not applicable.Patient(s): Men who have undergone exogenous testosterone (T) and/or anabolic androgenic steroid (AAS) therapies.Intervention(s): None.Main Outcome Measure(s): Semen analysis, pregnancy outcomes, and time to recovery of spermatogenesis.Result(s): Exogenous testosterone and […]

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Identification of HESX1 mutations in Kallmann syndrome

Objective: To determine whether HESX1 mutations are present in patients with idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS).Design: Polymerase chain reaction–based DNA sequencing was performed on 217 well-characterized IHH/KS patients. Putative missense mutations were analyzed by sorting intolerant from tolerant (SIFT) and Clustal ?.Setting: Academic medical center.Patient(s): Two hundred seventeen patients with IHH/KS and 192 controls.Intervention(s): […]

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Interindividual concurrence in interpretation of findings of hysteroscopic videos

Most readers of the report of Smit et al.'s report will be quite surprised regarding their principle finding, namely, the inability of international expert hysteroscopists to agree on the differentiation of normal versus arcuate versus septate uterine contours based on the appearance of the cavity. The authors posted eight videos (seven arcuate or septate and one […]

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Intracytoplasmic sperm injection outcome of ejaculated versus extracted testicular spermatozoa in cryptozoospermic men

Objective: To compare intracytoplasmic sperm injection (ICSI) outcome of patients with cryptozoospermia after use of ejaculated versus testicular sperm in different cycles of the same patients.Design: Retrospective cohort study.Setting: University-affiliated infertility center.Patient(s): A total of 17 patients with cryptozoospermia who underwent a total of 116 ICSI cycles.Intervention(s): The patients initially underwent several ICSI cycles using […]

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Determinants of testosterone recovery after bariatric surgery: is it only a matter of reduction of body mass index?

Objective: To explore the correlation models between body mass index (BMI) and sex hormones constructed from a male cross-sectional survey and evaluate the effects of surgery-induced weight loss on sex hormones in morbidly obese subjects that are not predicted by the constructed BMI correlation models.Design: Cross-sectional population and longitudinal studies.Setting: Bariatric surgery center in a […]

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Vasectomy demographics and postvasectomy desire for future children: results from a contemporary national survey

Objective: To describe the longitudinal demographics and family planning attitudes of vasectomized men with the use of the National Survey for Family Growth (NSFG).Design: Retrospective cohort analysis of the NSFG with the use of national projections and multivariable regressions.Setting: In-home survey.Patient(s): The NSFG sampled 10,403 men aged 15–45 years from 2006 to 2010 regarding family […]

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Prospective controlled study to evaluate laboratory and clinical outcomes of oocyte vitrification obtained in in vitro fertilization patients aged 30 to 39 years

Objective: To determine whether the process of oocyte vitrification affects oocyte viability in in vitro fertilization (IVF) patients between 30 and 39 years of age.Design: Prospective controlled study.Setting: Private IVF practice.Patient(s): A total of 30 women assigned and 22 qualified.Intervention(s): Denudation of oocytes, cryopreservation of oocytes using vitrification method in a medium with 15% ethylene glycol […]

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Phenotypic differences in children conceived from fresh and thawed embryos in in vitro fertilization compared with naturally conceived children

Objective: To determine whether anthropometric and biochemical features differ in in vitro fertilization (IVF) children conceived via fresh (IVFF) or thawed (IVFT) embryo transfer compared with naturally conceived controls.Design: A cross-sectional controlled study.Setting: University clinical research unit.Patient(s): Healthy prepubertal children (3.5–11.0 years), singletons, born at term (>37 weeks), who were either naturally conceived (controls; n = […]

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Personalized prediction of first-cycle in vitro fertilization success

Objective: To test whether the probability of having a live birth (LB) with the first IVF cycle (C1) can be predicted and personalized for patients in diverse environments.Design: Retrospective validation of multicenter prediction model.Setting: Three university-affiliated outpatient IVF clinics located in different countries.Patient(s): Using primary models aggregated from >13,000 C1s, we applied the boosted tree […]

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Three-dimensional power Doppler study of endometrial and subendometrial microvascularization in women with intrauterine device–induced menorrhagia

Objective: To evaluate endometrial and subendometrial microvascularization, using three-dimensional (3D) power Doppler ultrasound, in women with intrauterine device (IUD)-induced menorrhagia; and whether those potential findings could predict the risk of bleeding before IUD insertion.Design: Prospective clinical trial.Setting: University teaching hospital.Patient(s): One hundred twenty women, who requested the insertion of a copper IUD for contraception.Intervention(s): Endometrial […]

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Effect of prior birth and miscarriage frequency on the prevalence of acquired and congenital uterine anomalies in women with recurrent miscarriage: a cross-sectional study

Objective: To determine whether a prior live birth or an increase in number of miscarriages impacted the prevalence of congenital or acquired uterine anomalies in women with predominantly early recurrent miscarriage (RM).Design: Single-center, cross-sectional study.Setting: Patients with RM at a private practice.Patient(s): Eight hundred seventy-five women who had two or more consecutive miscarriages.Intervention(s): None.Main Outcome […]

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A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage

Objective: To confirm the effect of single nucleotide polymorphisms (SNPs) in chorionic gonadotropin beta (CGB) genes in modulating the susceptibility to recurrent miscarriage (RM) in Danes and in a meta-analysis across Danes and the discovery samples from Estonia and Finland.Design: Case-control association study, restriction fragment length polymorphism genotyping, resequencing.Setting: Fertility clinics at the Rigshospitalet, Copenhagen, […]

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Elective single embryo transfer trends and predictors of a good perinatal outcome—United States, 1999 to 2010

Objective: To assess trends in elective single ET and identify factors associated with a good perinatal outcome.Design: Retrospective cohort study.Setting: Clinic-based data.Patient(s): A total of 886,686 fresh, nondonor cycles reported to the National Assisted Reproductive Technology Surveillance System during 1999–2010, of which 17,166 met criteria for elective single ET.Intervention(s): None.Main Outcome Measure(s): Rates of elective […]

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Volitional determinants and age-related decline in fecundability: a general population prospective cohort study in Denmark

Objective: To quantify the natural decline in fecundability by age and assess the effect of selected volitional factors.Design: Prospective cohort study of women attempting conception.Setting: Not applicable.Participant(s): A total of 2,820 women without infertility, trying to conceive for less than 3 cycles at study entry.Intervention(s): None.Main Outcome Measure(s): Fecundability.Result(s): Age had little effect on fecundability […]

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Augmented epithelial multidrug resistance–associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A4

Objective: To compare the expression of the prostaglandin (PG) E2 transporter multidrug resistance–associated protein 4 (MRP4) in eutopic and ectopic endometrial tissue from endometriosis patients with that of control subjects and to examine whether MRP4 is regulated by the antiinflammatory lipid lipoxin A4 (LXA4) in endometriotic epithelial cells.Design: Molecular analysis in human samples and a […]

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The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions

Objective: To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases.Design: Retrospective study.Setting: Academic department and referral center for endometriosis.Patient(s): A consecutive series of 516 women who underwent excision […]

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Transcriptional changes in the expression of chemokines related to natural killer and T-regulatory cells in patients with deep infiltrative endometriosis

Objective: To evaluate the expression of chemokines that regulate natural killer (NK) and T-regulatory (T-reg) cell activity in eutopic and ectopic endometrial tissue samples from endometriosis patients.Design: Case-control study (Canadian Task Force classification II-2).Setting: Tertiary referral hospital.Patient(s): Sixty-four consecutive patients with and without endometriosis.Intervention(s): After videolaparoscopy, patients were divided into three groups: bowel endometriosis (n […]

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